Publication Information

{'id': 'https://openalex.org/W2393808177', 'doi': None, 'title': 'Influence of Phenobarbital Induction on the Stereoselectivity of Propranolol Glucuronidation in Rat Hepatic Microsome', 'display_name': 'Influence of Phenobarbital Induction on the Stereoselectivity of Propranolol Glucuronidation in Rat Hepatic Microsome', 'publication_year': 1999, 'publication_date': '1999-01-01', 'ids': {'openalex': 'https://openalex.org/W2393808177', 'mag': '2393808177'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZJYB199905003.htm', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 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'https://openalex.org/W1993258802', 'https://openalex.org/W1979143756', 'https://openalex.org/W1845182550'], 'abstract_inverted_index': {'Objective:To': [0], 'compare': [1], 'the': [2, 13, 19, 101, 106, 121, 134], 'glucuronidation': [3, 20, 35, 89, 113, 130], 'stereoselectivities': [4], 'of': [5, 15, 21, 66, 76, 81, 90, 98, 103, 124, 136], 'propranolol': [6, 22, 44, 83, 91, 112, 129], 'in': [7, 46, 51, 92, 114], 'rat': [8, 93, 115, 125], 'hepatic': [9, 24, 94, 116, 126], 'microsome': [10, 25, 47, 95, 127], 'and': [11, 28, 56, 64, 74, 110, 131], 'study': [12], 'influence': [14], 'inducer': [16], 'PB': [17, 29, 104, 118], 'on': [18], 'enantiomers.Methods:Rat': [23], 'from': [26], 'control': [27], 'induced': [30], 'rats': [31], 'were': [32, 49], 'prepared': [33], 'for': [34], 'reaction.A': [36], 'RP': [37], 'HPLC': [38], 'method': [39], 'was': [40, 84], 'used': [41], 'to': [42, 128], 'determine': [43], 'concentrations': [45], 'incubations.Results:Stereoselectivities': [48], 'observed': [50], 'enzymatic': [52], 'affinity(Km),maximum': [53], 'reaction': [54], 'speed(Vmax)': [55], 'intrinsic': [57], 'clearance': [58], '(Clint).PB': [59], 'induction': [60, 102, 119], 'singnificantly': [61], 'increased': [62], 'Vmax': [63, 75], 'Clint': [65, 80], 'R(+)': [67, 109], 'propranolol(': [68], 'P': [69, 78, 87], '0.01': [70], 'or': [71], '0.001),and': [72], 'Km': [73], 'S(-)propranolol(': [77], '0.001);but': [79], 'S(-)': [82, 99, 111, 137], 'significantly': [85], 'lowed(': [86], '0.05).The': [88], 'has': [96], 'stereoselectivity': [97, 135], 'propranolol,and': [100], 'reduced': [105], 'difference': [107], 'between': [108], 'microsome.Conclusion:The': [117], 'changed': [120], 'catalysis': [122], 'abilities': [123], 'still': [132], 'remained': [133], 'propranolol.': [138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2393808177', 'counts_by_year': [], 'updated_date': '2024-12-06T23:30:05.604412', 'created_date': '2016-06-24'}