Title: Experience of diagnosis and treatment of primary thyroid lymphoma(PTL)
Abstract: Objective:To discuss the principles of diagnosis and treatment of primary thyroid lymphoma (PTL).Methods:The clinical data,including clinicopathologic features,treatment and prognosis of 10 PTL patients were reviewed.Results:The patients included 6 women and 4 men,with an average age of 59 years and symptoms duration of 10 months.The level of serum TGAb and TPOAb increased in 7 cases.Histopathology of the 10 patients determined 3 different subtypes:3 B-cell lymphoma of mucosal-associated lymphoid tissue (MALT),4 diffuse large B cell lymphoma (DLBCL),3 DLBCL with MALT lymphoma.Hashimoto's disease or chronic lymphocytic thyroiditis were found in 4 cases.4 cases were stage ⅠE,2 stage Ⅱ2 stage ⅢE,2 cases were stage ⅣE,2 patients had incisional thyroid biopsy,8 patients had thyroidectomy with 1 having tracheostomy.10 patients received chemotherapy after surgery,in which 8 cases were treated with combined-modality approaches.The median follow-up for 10 cases was 30 months,10 were alive with median survival of 36 months.One patient with DLBCL stage ⅢE and one DLBCL with MALT lymphoma stage ⅣE died.Conclusion:Symptoms of rapid thyroid enlargment or nodule in old patients with chronic lymphocytic thyroiditis or Hashimoto's disease should be emphasized.Surgery mainly plays a role of providing an adequate diagnostic biopsy for PTL.Chemotherapy and radiotherapy are the standard treatments for PTL.Patients with MALT lymphoma or stageⅠ-Ⅱ have a good prognosis.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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