Title: Protective effects of curcumin on X-ray radiation damage of testis tissue in male rats
Abstract: Objective To examine the effectiveness of curcumin on X-ray radiation damage of testis tissue in male rats.Methods Male Sprague-Dawley rats(n=60,160~180 g) were divided randomly into 4 groups.Rats in group A served as controls.Rats in group B(radiation group) underwent whole-body X-ray exposure at the dose of 2.0 Gy.Rats in group C and D received DMSO and curcumin respectively 1 hour after 2.0 Gy irradiation.Testicular tissues were prepared 1 week after irradiation.Superoxide dismutase(SOD) activities,glutathione peroxidase(GSHPx) activities,and concentration of malondialdehyde(MDA) were detected.Moreover,the spermatogenic ce1l apoptosis was visualized with TUNEL.Results SOD activities and GSHPx activities in group B and C decreased as compared with those of the controls(P0.01).Curcumin treatment significantly increased SOD activities and GSHPx activities(P0.05).The MDA concentration in group B and C increased as compared with that of the controls(P0.01).Curcumin treatment significantly reduced the MDA concentration(P0.01).Irradiation significantly decreased the testis weight(P0.01).Curcumin treatment significantly restrained the decrease in testis weight(P0.01).Apoptosis indexes in group B and C significantly increased compared with those in the controls(P0.01).Curcumin treatment significantly reduced the apoptosis index.Conclusions The results provide a biochemical and histopathological basis to indicate that curcumin acts as a therapeutic agent for the testicular damage induced by X-ray exposure.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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