Title: Effect of Sanqidanshen Tablet on Experimental Liver Fibrosis Induced by CC1_4 in Mice
Abstract: Objective To study the protective effect of Sanqidanshen tablet against liver fibrosis(LF)induced by CC14 in mice. Methods The experimental LF model was induced by subcutaneous injection CC14 twice a week for 6w in mice. Sanqidanshen tablet (1g/kg)or Colchicine(0.1mg/kg)were administered intragastrically once a day for 6w. Serum levels of ALT,AST,albumin,HA,LN,PCⅢ and Ⅳ-C were determined. The pathological changes of hepatic tissues and grade of liver inflammation and stage of liver fibrosis(GS)were analyzed. Results Serum levels of ALT,AST,HA,LN,PCⅢ and Ⅳ-C in the treatment groups were obviously lower than that in the model group,and the patho- logical results under microscope and degree of GS were much better as compared with the model group. Conclusion The results suggest that Sanqidanshen tablet show preventive effect against LF induced by CC14.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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