Title: The Effects of Hemodynamic Reponse to Tracheal Intubation During Induction with Different Doses of Remifentanil in Combination of Propofol
Abstract: OBJECTIVE To compare the hemodynamic changes after anesthesia induction with different doses of remifentanil in combination of propofol.METHODS Forty-five ASAⅠ-Ⅱpatients undergoing electived surgery under general anesthesia were enrollde in this study.The patients were randomized to receive remifentanil 1,2,3μg·mg~(-1) except for difficulty in tracheal intubation Propofol were injected with 10mg·10~(-1)second until loss of conscious(LOC,no reponse to voice commend and loss of eyelash reflex).Tracheal was then intubated intubated following intravenous rocuronium 0.6mg·kg~(-1).We measured artial blood pressure and heart rate(HR)before anesthesia,induction after induction 1min,2min,3min,4min,5min,after intubation and induction complications like cough muscle rigid were observed.RESULTS Patients basic cindition were similar in three groups.The propofol dose of anesthesia induction was higher in group R_1 than in group R_2 and group R_3.Arterial blood pressure decreased signigicantly after induction compared with baseline valus,and BP after intubaion of were signigicantly higher than those before intubaion,but there were no signigicantly change in either group.HR remained stable after induction of anesthesia The incidence of intubaion reponse was higher in group R_1 complications like cough,muscle rigid circulation depression during induction were higher in group R_3 compared with group R_1 and group R_2.CONCLUSION Induction with different doses of remifentanil in combination of propofol provide positive interaction and the Remifentanil 2μg·mg~(-1)is a suitable dose which can effectively attenuate the intubation response.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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