Title: Protective Effects of Verapamil on Ischemia-Reperfusion Injury for Resection of Human Liver
Abstract: Objective:To study the protective effect of calcium block agents,verapamil against ischemia-reperfusion injury of human liver.Methods:Fourty patients for lobe/section hepatectomy were randomly divided into two groups.Verapamil group(test group),the 20 patients with lobe hepatectomy were given 5mg verapamil in 20mL saline by right gastroepiploic vein before blocking portra hepatis.Physiologic saline group(control group),were injected 20mL saline only in the same way.The routine Pringle's maneuver hepatic vascular occlusion in 15~17 min.Liver intracellular[Ca 2+ ]i after being reperfused for 1 h were measured as well as the hepatic histopathologic alterlations were also examined.The variation of postoperative liver function and arterial ketone body ratio were measured.Results:The levels of free calcium ions in the hepatic cell and serum enzyme from the test group increased not more significantly than those of the control group.The degree of hepatic pathological injury was lower and the hepatic function restored earlier in verapamil group.Conclusion:Given verapamil by hepatic portal vein before blocking porta hepatis,which shows and important protective effect against hepatic ischemia-reperfusion injury for resection of liver and have benefit for recovery of patients.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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