Title: Correlations of microvessel quantitation in colorectal tumors and clinicopathology
Abstract: AIM To evaluate the angiogenesis in colorectal tumorigenesis and to assess the prognostic significance of microvessel quantitation (MVD). METHODS Thirty two large bowel carcinomas, 5 adenomas and 10 normal mucosa (served as controls) were studied. Endothelial cells were immunostained with an anti CD31 mAb. Three microscopic fields (×200) in each case with the highest number of microvessels were counted, the average value of the three fields was used to evaluate the significance of microvessel density (MVD). RESULTS Anti CD31 mAb provided reliable and selective immunostaining of endothelial cells. MVD was 11±4 in normal mucosa, 28±11 in adenomas, and 50±22 in carcinomas (normal versus adenomas, P 0 05; normal versus carcinomas, P 0 01; adenomas or normal versus carcinomas, P 0 05). According to the tumor differentiation and stage, the evaluation of MVD had difference, but not significant. High MVDs were associated with patient shorter survival (0 10 P 0 05). CONCLUSION Angiogenesis is a critical step in colorectal tumorigenesis. MVD can predict prognosis of colorectal cancer patients.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 5
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot