Title: Clinical application of sentinel lymph node technology in early gastric carcinoma and micrometastasis detection
Abstract: Objective: To investigate the application of sentinel lymph node biopsy to early gastric carcinoma and clinical significance of sentinel lymph node micrometastasis detection.Methods: 34 patients with early gastric carcinoma intraoperatively underwent sentinel lymph node biopsy with methylene blue.All SLNs were studied with HE and keratin monoclonal antibody AE1/AE3 immunohistochemistry.Results: The stained SLNs could be identified in 33(97.1%) of 34 patients.The accuracy of the SLN status in diagnosis of the lymph node status of the patients was 93.9%.Sensitivity was 88.9%.The specificity and false-negative rate were 100.0% and 11.1%,respectively.The metastasis detection of SLN with immunohistochemistry had significant difference,compared with the routine pathologic examination(P=0.034).12 SLNs were found to have micrometastasis in 8 patients by immunohistochemical technology.Conclusions: SLN can explore the feature of lymph node metastasis in early gastric carcinoma,immunohistochemistry is more sensitive than HE in the exploration of lymph node metastasis.AE1/AE3 immunohistochemistry can improve the efficiency of detecting micrometastasis in SLNs,which has positive clinical significance for definition of clinical stage,treatment and prognosis in early gastric carcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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