Title: Pharmacokinetics and relative bioavailability of glipizide tablets in healthy volunteers
Abstract: Aim: To study the pharmacokinetics and relative bioavailability of glipizide in healthy volunteers. Methods: The plasma concentrations of glipizide were determined by HPLC in 9 healthy male volunteers after an oral dose of 5 mg standard or tested formulation in crossways. Results: The concentration time curves of the 2 formulations were all fit to the one compartment open model.The T max values were (3.67±0.50)h and (3.33±0.50)h, the C max values were (391±37) μg·L -1 and (400±35) μg·L -1 , the AUC were (2.46±0.39)μg·h·L -1 and (2.23± 0.88) μg·h·L -1 for standard and tested formulations, respectively.The relative bioavailability of the tested formulation was (102.9±15.7)%. Conclusion: The 2 formulations were bioequivalent.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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