Title: Expression of STAT5 and BAX in NSCLC and their correlation
Abstract: Objective To examine the expression of STAT5 and BAX in NSCLC and to study their relationship.Methods STAT5 and BAX proteins were detected in formalin-fixed paraffin-embedded tissue from 68 non-small cell lung cancer tissues and 26 normal lung tissues by SP immunohistochemical method.The levels of their expression and their relationship with STAT5 and BAX were analyzed.Results ①The positive rates of STAT5 and BAX in NSCLC were dramatically higher than those in the normal lung tissues(P0.01);②There are some expression of Bax in NSCLC,but no difference between NSCLC and normal lung tissues was found.③The expression of STAT5 was significantly correlated with histological types of NSCLC(P0.01),and was higher in adenocarcinomas than in squamous carcinomas;④The expression of BAX was significantly correlated with histological grading,TNM stage and lymph node metastasis(P0.05),respectively,but was not correlated with the histological types of NSCLC(P0.05).⑤There was significantly positive association between STAT5 and BAX.Conclusion The high expression of STAT5 and BAX in NSCLC plays important roles in occurrence,invasion and metastasis of NSCLC.The inhibition of STAT5 signal pathway may become a therapeutic target.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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