Publication Information

{'id': 'https://openalex.org/W2392834505', 'doi': None, 'title': 'Nicotinamide phosphoribosyltransferase inhibitors in cancer therapy:an advance', 'display_name': 'Nicotinamide phosphoribosyltransferase inhibitors in cancer therapy:an advance', 'publication_year': 2012, 'publication_date': '2012-01-01', 'ids': {'openalex': 'https://openalex.org/W2392834505', 'mag': '2392834505'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-DEJD201207019.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S112952355', 'display_name': 'Academic Journal of Second Military Medical University', 'issn_l': '0258-879X', 'issn': ['0258-879X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319982', 'host_organization_name': 'Science Press', 'host_organization_lineage': ['https://openalex.org/P4310319982'], 'host_organization_lineage_names': ['Science Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100950332', 'display_name': 'Miao Chao-yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Miao Chao-yu', 'raw_affiliation_strings': ['Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China', 'institution_ids': ['https://openalex.org/I177933477']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5100950332'], 'corresponding_institution_ids': ['https://openalex.org/I177933477'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.399457, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 64, 'max': 72}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12827', 'display_name': 'Biochemical and Molecular Research', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nicotinamide-phosphoribosyltransferase', 'display_name': 'Nicotinamide phosphoribosyltransferase', 'score': 0.99118364}, {'id': 'https://openalex.org/keywords/nicotinamide-mononucleotide', 'display_name': 'Nicotinamide mononucleotide', 'score': 0.47508588}, {'id': 'https://openalex.org/keywords/limiting', 'display_name': 'Limiting', 'score': 0.4381334}], 'concepts': [{'id': 'https://openalex.org/C2780391879', 'wikidata': 'https://www.wikidata.org/wiki/Q18035058', 'display_name': 'Nicotinamide phosphoribosyltransferase', 'level': 4, 'score': 0.99118364}, {'id': 'https://openalex.org/C75520062', 'wikidata': 'https://www.wikidata.org/wiki/Q15321392', 'display_name': 'NAD+ kinase', 'level': 3, 'score': 0.95857286}, {'id': 'https://openalex.org/C2776901170', 'wikidata': 'https://www.wikidata.org/wiki/Q12499775', 'display_name': 'Nicotinamide adenine dinucleotide', 'level': 4, 'score': 0.82561404}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.60514385}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.574114}, {'id': 'https://openalex.org/C197957613', 'wikidata': 'https://www.wikidata.org/wiki/Q407280', 'display_name': 'Cofactor', 'level': 3, 'score': 0.56446874}, {'id': 'https://openalex.org/C2779728014', 'wikidata': 'https://www.wikidata.org/wiki/Q192423', 'display_name': 'Nicotinamide', 'level': 3, 'score': 0.5176471}, {'id': 'https://openalex.org/C2777088662', 'wikidata': 'https://www.wikidata.org/wiki/Q21547155', 'display_name': 'Nicotinamide mononucleotide', 'level': 5, 'score': 0.47508588}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44388384}, {'id': 'https://openalex.org/C188198153', 'wikidata': 'https://www.wikidata.org/wiki/Q1613840', 'display_name': 'Limiting', 'level': 2, 'score': 0.4381334}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43560725}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4322766}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36269516}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34031928}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09131709}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-DEJD201207019.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S112952355', 'display_name': 'Academic Journal of Second Military Medical University', 'issn_l': '0258-879X', 'issn': ['0258-879X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319982', 'host_organization_name': 'Science Press', 'host_organization_lineage': ['https://openalex.org/P4310319982'], 'host_organization_lineage_names': ['Science Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7', 'score': 0.51}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W434316380', 'https://openalex.org/W3211080599', 'https://openalex.org/W3148321246', 'https://openalex.org/W3025899813', 'https://openalex.org/W2977435042', 'https://openalex.org/W2831675724', 'https://openalex.org/W2802609110', 'https://openalex.org/W2790817297', 'https://openalex.org/W2789953470', 'https://openalex.org/W2614739798', 'https://openalex.org/W2611439401', 'https://openalex.org/W2606055193', 'https://openalex.org/W2604146407', 'https://openalex.org/W2603222534', 'https://openalex.org/W2600523387', 'https://openalex.org/W2504248438', 'https://openalex.org/W2474462601', 'https://openalex.org/W2371754966', 'https://openalex.org/W2088337804', 'https://openalex.org/W1981106431'], 'abstract_inverted_index': {'Nicotinamide': [0], 'adenine': [1], 'dinucleotide(NAD)': [2], 'plays': [3], 'a': [4, 13, 41], 'crucial': [5], 'role': [6], 'in': [7, 15, 21, 32, 44, 120], 'many': [8], 'cellular': [9, 37], 'processes.It': [10], 'functions': [11], 'as': [12], 'cofactor': [14], 'more': [16, 57, 64], 'than': [17, 69], '200': [18], 'oxidation-reduction': [19], 'reactions': [20], 'humans.As': [22], 'the': [23, 27, 36, 60, 81, 114, 125], 'rate-limiting': [24], 'enzyme': [25], 'of': [26, 83, 117, 129], 'predominant': [28], 'NAD': [29, 38, 61], 'biosynthesis': [30], 'pathway': [31], 'mammals,nicotinamide': [33], 'phosphoribosyltransferase(Nampt)': [34], 'regulates': [35], 'level.Nampt': [39], 'is': [40], 'key': [42], 'protein': [43], 'biochemical': [45], 'processes': [46], 'and': [47, 50, 79, 127], 'energy': [48], 'metabolism': [49], 'has': [51, 76], 'various': [52], 'biological': [53], 'activities.Tumor': [54], 'cells': [55], 'are': [56], 'sensitive': [58], 'to': [59, 66], 'levels,making': [62], 'them': [63], 'susceptible': [65], 'Nampt': [67, 75, 88, 96, 105, 118, 130], 'inhibition': [68], 'normal': [70], 'cells.Experimental': [71], 'evidence': [72, 123], 'indicates': [73], 'that': [74], 'proangiogenic': [77], 'activity': [78], 'supports': [80], 'growth': [82], 'some': [84], 'tumors.These': [85], 'findings': [86], 'make': [87], 'attractive': [89], 'for': [90, 101, 124], 'pharmaceutical': [91], 'research': [92], 'during': [93], 'recent': [94, 115], 'years,and': [95], 'inhibitors': [97, 106, 119], 'might': [98], 'be': [99], 'used': [100], 'tumor': [102], 'chemotherapy.Currently': [103], '4': [104], 'have': [107], 'been': [108], 'reported:': [109], 'FK866,CHS828,CB30865,and': [110], 'IS001.Here': [111], 'we': [112], 'review': [113], 'progress': [116], 'cancer': [121], 'therapy,providing': [122], 'development': [126], 'application': [128], 'regulating': [131], 'agents.': [132]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2392834505', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-07T15:47:01.621167', 'created_date': '2016-06-24'}