Title: Ethanol administrastions in pregnant rats cause morphological changes in fetus
Abstract:ObjectiveTo establish a rat model of fetal alcohol syndrome and to understand the morphological changes of the rat model.MethodsTwenty adult female rats were given drinking water with successively inc...ObjectiveTo establish a rat model of fetal alcohol syndrome and to understand the morphological changes of the rat model.MethodsTwenty adult female rats were given drinking water with successively increased concentration of ethanol before pregnancy,starting at a concentration of 3 % and ending at 20 %(v/v).Pregnant rats were randomly divided into two groups.Ethanol drinking group were provided liquid diet containing 20 %(v/v)ethanal and were maintained on this diet for 4 days.Control group received a normal diet without ethanol.Morphological characteristics of fetus and newborns in each group were evaluated.ResultsHead length,body length,body weight,interocular breadth and palpebral fissure length of newborn rats in ethanol drinking group were significantly decreased than in control group.There were three outcomes shown in fetus of ethanol drinking group:normal fetus,malformed placenta with resorbed fetus and malformed fetus.ConclusionMorphological changes related to the developmental toxicity were found in rat model of fetal alcohol syndrome.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot