Title: Influence of rabeprazole on the antiplatelet action of clopidogrel
Abstract:Objective To investigate the impact of the proton pump inhibitor(PPI)Rabeprazole on platelet aggregation in patients receiving clopidogrel and percutaneous coronary intervention(PCI).Methods One hundr...Objective To investigate the impact of the proton pump inhibitor(PPI)Rabeprazole on platelet aggregation in patients receiving clopidogrel and percutaneous coronary intervention(PCI).Methods One hundred and twenty elective PCI patients who were prescribed with aspirin and clopidogrel,were randomized to the Rabeprazole group(n = 60,Rabeprazole 20 mg/day)or the control group(n = 60).Adenosine diphosphate(ADP)-induced platelet aggregation was measured to evaluate the antiplatelet effect of Clopidogrel after 7 days in both groups.Major adverse coronary events(MACE)and occult blood test(OBT)were recorded and analysed during clinical follow-up of 1 months.Results ADP-induced platelet aggregation was 32.4% in the Rabeprazole group and 37.1% in the Control group(P = 0.1971).The incidence of MACE was similar between the Rabeprazole group and the Control groups(3.3% vs 5%,P = 0.6478).No patient in the Rabeprazole group had positive OBT.Four patients(6.7%)had positive OBT in the Control group during hospitalization,and five patients(8.3%)in one month follow-up.Conclusion Among patients undergoing PCI treated with aspirin and clopidogrel,rabeprazole could protect the gastrointestinal tract mucosa and reduce alimentary tract hemorrhage without influencing the antiplatelet effect of clopidogrel.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot