Title: Preliminary Study of the Clinical Value of Voxel-based Morphometry Technique in Alzheimer′s Disease and Mild Cognition Impairment
Abstract: Objective:Using voxel based morphometry(VBM) technique to compare the differences of grey matter volume in Alzheimer′s disease(AD),mild cognition impairment(MCI) and normal healthy aged volunteers and to evaluate the clinical value of VBM in the diagnosis of AD and MCI.Methods:10 AD patients,9 MCI patients and 10 volunteers were included in the study.MRI with routine axial T2WI,T1WI,FLAIR;sagittal plane T1WI sequences and whole brain 3D-SPGR images were performed.All data were studied by VBM technique,the brain was segmented to grey matter,white matter and cerebral spinal fluid(CSF),lastly t test was used to compare the grey matter volume of every two groups in this study.Results:Comparison of AD and normal aged volunteers,the grey matter volume of AD was much less than that of normal volunteers,the activated area distributed in almost the whole hemisphere cortex,especially the medial temporal lobe(hippocampus,pyriform cortex,internal olfactory cortex).The total voxel number reduced in the right hippocampus were 2358 and in the left were 2967,the voxel number in anterior and posterior of gyri cinguli were markedly reduced too.Comparison of MCI and normal groups,the reduction area of grey matter was still obvious,but compared with that of AD,the activated areas were markedly lesser,especially the internal olfactory cortex of medial temparal lobe and pare-hippocampus gyri area.The total reduction voxel numbers in the right were 1368 and in the left were 1135.Comparison of AD and MCI patients,the reduction area of grey matter in MCI were more than that of AD,basically there was no activated area in hippocampus and medial temporal lobe.The more obviously activated regions located at bilateral frontal,parietal and temporal lobes and gyri cinguli.There were relatively obviously activated regions in bilateral caudate nucleus head and left thalamus,yet no obvious activation was assessed in nucleus lentiformis.Conclusion:Reduction of the volume of medial temporal lobe and hippocampus is the most sensitive approach in the evaluation of AD and MCI.VBM is a valuable technique to evaluate the change of grey matter volume.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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