Title: Advances on Microbial Biosynthesis and Fermentation Production of Lycopene
Abstract: Microbial fermentation is the optimal method for lycopene production. There are two biosynthetic pathway of lycopene including MEP(2-methyl-derythritol-4-phosphate) pathway and MVA(Mevalonic acid) pathway. The key relevant enzymes for lycopene biosynthesis includes isopentenyl diphosphate isomerase(IPI), geranyl pyrophosphate sythase(GPS), farnesyl pyrophosphate sythase(FPS), geranylgeranyl pyrophoaphate sythase(GGPS), phytoene synthase(PSY), phytoene desaturase(PDS), ζ-carotenedesaturase(ZDS) and carotene isomerase(CRTISO). The synthesis pathway and the yield of lycopene could be improved by regulating and modifying the key enzymes through mutation, genetic recombination and gene knockout method. In recent years, extensive research has been carried on microbial fermentation production of lycopene using bacteria, fungi, yeast and other microorganisms and several novel technologies for fermentation synthesis of lycopene are developed, which provides insights for improving the yield and reducing the costs of lycopene. This article reviewed the synthesis and production of lycopene by microbial fermentation and the aim was to provide new ideas and directions on development and application of lycopene.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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Cited By Count: 1
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