Title: Median Effective Concentration of Ropivacaine for Ultrasound-Guided Supraclavicular Brachial Plexus Block
Abstract: Objective To determine the median effective concentration(EC50)of ropivacaine for ultrasound-guided supraclavicular brachial plexus block.Methods Forty ASA ⅠorⅡpatients scheduled for hand or forearm surgery were given double point injection with 30mL ropivacaine for ultrasound-guided supraclavicular brachial plexus block.The ropivacaine was injected at concentrations of 0.15%,0.20%,0.25%,0.30% and 0.35%.The initial concentration was 0.25% and the concentration interval was 0.05%.The anesthetic efficacy was assessed with visual analogue scale(VAS)30minutes after ropivacaine injection.General anesthesia was performed in patients with VAS score greater than 3and the next case was given higher concentration of ropivacaine.If VAS score was less than 3,the next case was given lower concentration of ropivacaine.The EC50of ropivacaine for ultrasound-guided supraclavicular brachial plexus block and the 95% confidence interval were calculated using probit analysis.Results The EC50of ropivacaine for ultrasound-guided supraclavicular brachial plexus block was 0.243%and the 95%confidence interval ranged from 0.219%to 0.266%.Conclusion The EC50of ropivacaine was 0.243%for ultrasound-guided supraclavicular brachial plexus block.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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