Title: Clinical implications of elevated plasma free fatty acids in type 2 diabetes mellitus and impaired glucose tolerance
Abstract: Objective To measure levels of free fatty acids(FFA)in patients with type 2 diabetes mellitus(2-DM)and impaired glucose tolerance(IGT),and to explore the relationship between FFA and insulin(INS),insulin resistance(IR)and triglycerides(TG). Methods The concentrations of FFA were measured by enzymatic colorimetric methods during fasting and after 2 h of 75 g oral glucose tolerance(OGTT).Fasting and 2 h after OGTT plasma glucose(PG)and INS levels were also measured by glucose oxides and RIA methods. All data were compared with 20 normal controls(NC).Results Fasting and 2 h after OGTT levels of PG and INS were significantly increased and fasting FFA, HbA1c and homeostasis insulin resistance(HOMA-IR)were also elevated significantly in patients with type 2-DM and IGT as compared with those in NC. The levels of TG and 2 h after OGTT FFA, however, were remarkably increased in type 2-DM compared with IGT and NC subjects, and no differences were found between groups of IGT and NC. In stepwise multivariate analysis, fasting FFA was the strongest predictors of HOMA-IR. Conclusion The results suggest that in patients with type 2-DM and IGT, the levels of FFA be significantly elevated, and exist IR and dyslipidemia. The elevated of FFA is correlated with IR .The levels of FFA are more sensitive than those of TG in reflected dyslipidemia.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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