Title: Study on drug-loaded nanoparticles transferring to bloodbrain barrier(BBB)
Abstract: Object To deliver nanoparticles through the blood-brain barrier(BBB),which represents an insurmountable obstacle for the delivery of a large number of drugs to the central nervous system(CNS).Methods Produce(TweenR 80)nanoparticles,and make it through the blood-brain barrier.The survival rate of mice was detected,and the capacity was tracked to absorb the brain capillary endothelial cells Results Experiments with the extremely aggressive glioblastoma transplanted intracranially showed a long term survival for 6 months of up to 40% of the rats after intravenous injection of the polysorbate 80-coated nanoparticle preparation.The mechanism of the drug through the blood-brain barrier with the nanoparticles appeared to be endocytotic uptake by brain capillary endothelial cells followed either by release of the drugs in these cells and diffusion into the brain or by transcytosis.Conclusions Polysorbate 80-coated nanoparticles represent a very promising preparation for the delivery of drugs across the blood-brain barrier.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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