Title: Detection of glucocorticoid receptor-α mRNA expression in thyroid adenomas
Abstract: Objective To detect the expression of glucocorticoid receptor-α(GR-α) mRNA in thyroid adenomas and thyroid gland tissues and its role in the development of thyroid adenomas.MethodsBy using fluorescent quantitative PCR(FQ-RT-PCR),the expression of GR-α mRNA was detected in 22 previously diagnosed cases of thyroid adenomas and thyroid gland tissues.Results GR-α mRNA levels in the normal thyroid were significantly higher than in thyroid adenomas((P)(0.05).)Conclusion GR-α was detectable in the thyroid adenoma and thyroid gland tissues.A downregulation of GR-α mRNA in thyroid adenoma seems to suggest that glucocorticoid is likely to play an important role in the development of thyroid adenomas.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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