Abstract: Aim To discuss the effect of atorvastatins on blood pressure and intima-media thickness(IMT)in patients with essential hypertension.Methods 78 patients with hypertension were selected,whose systolic blood pressure(SBP)was between 140 mmHg and 179 mmHg and diastolic blood pressure(DBP)was between 90 mmHg and 109 mmHg.The 39 EH patients with hypercholesterolemia(HC)and the rest without were randomized,double-blind,and assigned to atorvastatin(20 mg·d-1,NC group,n=19,HC group,n=20)and amlodipine(5 mg·d-1)or to the control group with amlodipine(5 mg·d-1)(no lipid-lower-drugs NC group,n=20,HC group,n=19)for 12 weeks.20 healthy people were selected as health control.Changes in blood pressure,blood cholesterol,and carotid arterial IMT were investigated respectively.Results Blood pressures decreased more markedly in patients taking statins no matter with or without hypercholesterolemia than in those not taking statins(P0.05).Compared with control group,there was a significant reduction in serum TC,TG and low density lipoprotein cholesterol concentrations in 20 mg atorvastatin group(P0.05)and high density lipoprotein cholesterol concentrations was higher.The level of BP,IMT/D and carotid arterial plaque in EH group was higher than that in health control group.After treatment of atorvastatin,IMT and IMT/D decreased markedly(P0.05),but carotid arterial plaque didn't develop obviously.Through the analysis of the results,we could see the tendency of improvement(P0.05).Conclusion Atorvastatin together with amlodipine can significantly lower blood pressure better.Modulating blood lipid effectively,it can develop IMT in short time,but not in carotid arterial plaque.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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