Title: Significance of soluble intercellular adhesion molecule-1expression in serun of patients with gastric carcinoma
Abstract:Objective:This study was to determine the serun level of soluble intercellular adhesion molecule-1(sICAM-1) in patients with gastric carcinoma and to elucidate the relation of its level with clinical ...Objective:This study was to determine the serun level of soluble intercellular adhesion molecule-1(sICAM-1) in patients with gastric carcinoma and to elucidate the relation of its level with clinical characteristics and metastasis of gastric cancer.Methods:The serun levels of soluble ICAM-1 were measured with enzyme linked immunosorbent assay in 15 healthy controls and 60 patients with gastric cancer before and after operation.Result:Serun concentration of sICAM-1 was significantly elevated in the patients with gastric cancer(142.22±21.58ng/ml)in compared with healthy control subjects(60.95±19.39ng/ml)(P0.01) ,and the levels of postoperative(n=15) sICAM-1 was significantly lower than preoperative's(154.35±15.67ng/ml)(P0.01). The level of sICAM-1 expression were closely correlated with invasion deep,with TNM stage,with lymph node metastasis.Conclusion:Examination of sICAM-1 in gastric cancer helps a lot in evaluating intensity of lymph node metastasis,TNM stage and prognosis. sICAM-1 might be valuable marker in assessing invasion and metastatic potential of gastric carcinoma.Read More
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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