Title: Relationship between nitric oxide levels in plasma and hyperdynamic circulation in cirrhotic patients
Abstract: Objective: To ascertain the role of nitric oxide(NO) in hemodynamic dysfunction in patients with liver cirrhosis. Methods: The plasma levels of NO and nitric oxide synthase (NOS) of 28 cirrhotic patients and 16 normal controls were measured by Griess and colorimetric methods. Meanwhile, cardiac output (CO), cardiac index (CI) and systemic vascular resistance (R) were determined. Results: Higher plasma levels of NO and NOS activity were observed in cirrhotic patients than those in normal controls (52.34 vs 36.95 μmol/L, P 0.05; 32.69 vs 21.24 μmol·L -1 ·min -1 , P 0.05). The worse the liver function, the higher the levels of plasma NO. In Child Pugh C cirrhotic patients, increased CO, CI (9.62 v s 4.84 L/min, P 0.01; 5.36 vs 3.62 L·min -1 ·m -2 , P 0.01) and decreased R (8.61 vs 12.12 Pa·s·m -3 , P 0.01) were found when compared with controls. The levels of NO had a positive correlation with CO and CI ( r =0.672, P 0.05; r =0.704, P 0.05) and had a negative correlation with R ( r =-0.586, P 0.05). Conclusion: NO is overproduced in patients with liver cirrhosis, and it might play an important role in hemodynamic dysfunction. [
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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