Title: Study of Effect of Oral Contrast Agent in Gastrointestinal ~(18)F-FDG Uptake
Abstract: Objective To investigate the influence of oral contrast agent to ~(18)F-FDG uptake in gastrointestinal tract. Methods 1.Phantom study: 10(2 cm diameter) glass vitals filled meglumine diatrizoate with various concentrations, and then put into a cylinder phantom containing 2.5 kBq/mL ~(18)F-FDG. The phantom was scanned with PET/CT scanner in 2D mode. ROIs were drawn within the contrast regions, the CT density and radioactivity in each ROI was calculated. 2.Clinical study: PET/CT images of 78 patients without abdominal uptake were reviewed. (Among) them, 32 cases did not receive any contrast agent before PET imaging while 46 cases were orally administered 1000 mL of 1% meglumine diatrizoate. ROIs were drawn in the area of stomach, jejunum, ileum, ascending colon, transverse colon, descending colon and rectum with CT image as a reference. The average standardized uptake value(SUV) and CT density in each ROI were obtained and analyzed. Results Phantom study showed that meglumine diatrizoate concentration was correlated with the radioactivity overestimation(P0.01). The average SUV of ascending colon, transverse colon and rectum in patients received oral contrast agent was significantly higher than that of control group (P0.05). After corrected the HU in ascending and transverse colon, the corrected SUV in ascending colon, and transverse colon groups were still high in patients who received oral contrast agent. Conclusion Oral contrast agent can increase the ~(18)F-FDG uptake in colon.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot