Title: Effects of Huoxue Simiao Decoction on renal tissue and CD40 expression in the hyperuricemia rats of early renal damage
Abstract: Objective: To observe the Huoxue Simiao Decoction on renal tissue and CD40 expression in the hyperuricemia rats of early renal damage, and to explore its mechanism of prevention and treatment. Methods: The hyperuricemia rat model of early renal damage was established by being gavaged with adenine and ethambutol. SD male rats were randomly divided into six groups: normal group, model group, allopurinol group, Huoxue Simiao Decoction low, middle and high dose groups. After 14 days of administration, bllood and material were collected. Uric acid and serum creatinine were respectively detected by colorimetric method, and HE staining, Masson staining, immunohistochemistry detection of renal CD40 were all measured. Results: Compared with normal group, the uric acid of model group was significantly higher(P0.05), and the expression of CD40 was increased(P0.05), the uric acid of Huoxue Simiao Decoction high and middle dose groups was significantly decreased(P0.05), the expression of CD40 of Huoxue Simiao Decoction low, middle and high dose groups were decreased significantly compared with the model group(P0.05), and the greater the dose, the better the outcome. Conclusion: Huoxue Simiao Decoction could regulate uric acid in rats with hyperuricemia. Its efficacy is associated with the decrease of CD40 expression.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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