Title: Distribution and significance of hepatitis B virus genotypes in She population
Abstract:Objective To investigate the distribution of hepatitis B virus(HBV) genotypes in She population compared with that in Han population also in Lishui area,and to further study the liver injuries and HBV...Objective To investigate the distribution of hepatitis B virus(HBV) genotypes in She population compared with that in Han population also in Lishui area,and to further study the liver injuries and HBV serum markers among She populations infected with HBV of different genotypes.Methods The genotypes of HBV DNA positive subjects were examined by real time fluorescence polymerize chain reaction and S gene sequencing,while ALT and AST by automatic biochemical analyzer and HBV serum markers by ELISA.Results 173 HBV DNA positive samples were screened from 1744 She population,and 78 were genotype B,92 genotype C,3 genotype B/C.The mean HBV DNA copy logarithm of subjects infected with HBV genotype B and C were 4.596±1.814 and 5.364±2.189 respectively.13 of those infected with HBV genotype B and 15 of genotype C were detected with enhanced ALT and AST;and 11 of genotype B and 26 of genotype C were HBeAg positive.The same number of Han populations were also examined as contrasts.Conclusions It can be concluded that She population in Lishui area is mainly infected with HBV genotype B and C,and genotype C takes more proportion,which is obviously different from Han population in the same area.For She population in Lishui,the HBV DNA copy and HBeAg positive rate of HBV genotype B are lower than those of HBV genotype C,which indicates that populations infected with HBV genotype B might have less active virus,lighter liver injuries and better prognosis.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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