Title: Serotype/serogroup distribution of Streptococcus pneumoniae isolated from clinical patients and surveillance on antimicrobial resistance in 2004—2009
Abstract: Objective To investigate serotype/serogroup distribution and the trend of antimicrobial resistance of Streptococcus pneumoniae isolated from patients hospitalized for pneumonia in Yiyang City Central Hospital,so as to provide the guidance for rational clinical treatment.Methods Eight hundred and twenty two strains of S.pneumoniae were collected from 2004 to 2009.The isolates were serotyped/serogrouped with the quellung reaction,and minimal inhibition concentrations (MIC) of Penicillin,Cefuroxime,Cefdinir,Cefaclor,Erythromycin,Tetracycline,Levofloxacin,and Vancomycin were determined by E-test.Results The prevalence of Penicillin-nonsusceptible S.pneumoniae (PNSP) isolates increased gradually from 49.4% in 2004 to a statistical peak in 2006 (67.8%),then decreased to 51.0% in 2009.Among 822 strains of S.pneumoniae,the most prevalent serotypes/serogroups are groups 19,23,6,14,3,and others.The distribution of six serotypes in PNSP isolates was not statistically different during the years (P 0.05).The prevalence of S.pneumoniae isolates nonsusceptible to other β-lactam antibiotics was similar to Penicillin.The prevalence of strains nonsusceptible to Erythromycin and Tetracycline was consistently 60%.Almost all PRSP were resistant to both Erythromycin and Tetracycline throughout the period.The prevalence of strains resistant to Levofloxacin and Vancomycin were 3% over the period.Conclusion Serotype/serogroup 19,23,6,14,and 3 are the commom groups in S.pneumoniae isolated from clinic patients.Decreased prevalence of β-lactam resistant strains has been occurring since 2007,and these S.pneumoniae strains are highly sensitive to Levofloxacin and Vancomycin consistantly.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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