Title: Quantitative comparison study of 16-slice spiral perfusion CT for pre-and post-radiotherapy of lung cancer vascularity
Abstract: Objective:To prospectively investigate tumor vascularity in lung cancer and to determine whether any of the perfusion parameters would predict tumor response to radiation therapy with 16-slice spiral CT.Methods:19 patients with lung cancer had perfusion CT before and after 4~5 weeks of radiation therapy followed by another two times of unenhanced CT scans in 3 and 6 months after radiation therapy respectively,to assessing the tumors size changes.Contrast medium-enhanced dynamic CT was performed with a static table position for 50 seconds,and the data were analyzed by using commercial software to calculate tissue blood flow(BF),blood volume(BV),mean transit time(MTT),and vascular permeability-surface area product.Perfusion parameters before and after radiation therapy were compared.Statistical analysis was performed with the Student t test.Results:After radiation therapy,tumors showed significant reduction in BF and increase in MTT in 13 patients.In all the patients,significant reduction in tumors size was seen in scheduled follow-up CT exeminations.No significantly difference in BF or in MTT was observed between CT scans obtained before and those obtained after radiation therapy in 5 patients.The data from 1 patient was not included in the analysis because of excessive motion during scanning.Conclusion:Perfusion CT of lung cancer can enable assessment of tumor vascularity and perfusion changes that result from radiation therapy.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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