Title: Significance of Expression of Nuclear Factor-κB in Brain Tissues of Rats with Repeated Febrile Seizures
Abstract: Objective To observe the expressions of nuclear factor-κB(NF-κB)in brain tissue of rats with repeated febrile seizures(FS)and explore its significance in brain injury of rats with FS.Methods Fifty-one male SD rats were divided into 3 groups according to random number method:normal group(n=14),hyperthermic group(n=19),FS group(n=18).FS models were induced by placing rats in warm bath;the rats without FS after warm-bath were assigned as hyperthermic group ;the normal controls received no treatment.The expression of NF-κB was measured by immunohistochemistry.The apoptosis of brain tissue was determined by terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling(TUNEL).SPSS 13.0 software was applied for statistical treatment.Results In FS group,the number of the NF-κB positive neuron increased much more than that of hyperthermic group and normal group(Pa0.01),and that in hyperthermic group was highter than that in normal group(Pa0.01).The number of NF-κB varied in dentate gyrus(DG)[(26.10±2.40)/HP],CA3 [(24.30±2.0)/HP],CA1 [(22.50±3.98)/HP],and cortex of temporal lobe(CTL)[(22.10±2.33)/HP].The expression characteristics were correlated with TUNEL.Apoptotic index from high to low were in DG(32.65±2.14),CA3(28.99±1.16),and CA1(24.28±0.92),and CTL(22.19±1.06).Conclusions The expression of NF-κB was different in the brain region after repeated FS and correlated with apoptosis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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