Title: Relationship between bioavailability in vivo and dissolution in vitro of nitrofurantoin tablets
Abstract: OBJECTIVE To study the correlation between the absorption in vivo and the dissolution in vitro of nitrofurantoin(NF) tablets,in order to illustrate the necessity of checking dissolution as a method of quality control of nitrofuran tablets.METHODS The dissolution rate of four brands of marketed nitrofuran tablets were checked according to the USP24th edition.The two brands with great difference of dissolution rate were administered in 10 healthy male volunteers.The NF concentrations in urine were determined by HPLC to evaluate the bioavailability.RESULTS Two brands with drug dissolution of 89% and 15% in 2 hours excreted unchanged nitrofuran in urine were 10.77% and 1.54%,respectively.The correlation between dissolution in vitro and absorption in vivo was significant.CONCLUSION The results showed the dissolution in vitro can be used as a reference criteria for primarily evaluating the bioavailability of nitrofurantion tablets.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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