Title: Analysis of Clindamycin-induced Resistance by Erythromycin among 772 Strains of Staphylococcus
Abstract: Objective:To study the drug resistance of erythromycin and clindamycin caused by Staphylococcus aureus, in combination with sensitivity test results, and to provide reference for clinical rational antibiotics use.Methods:Reference to the U.S.Committee for Clinical Laboratory Standards(NCCLS) recommended paper diffusion method.Surveying and evaluating the drug resistance of erythromycin and clindamycin caused by Staphylococcus aureus, and using D-test to find out the clindamycin resistance phenotype induced by erythromycin.Results:Erythromycin and clindamycin both had drug resistance:51.65% of erythromycin got resistent to methicillin resistant Staphylococcus aureus, and 34.57% of clindamycin got resistent to methicillin sensitive Staphylococcus aureus.Two bacterial strains which got resistent to erythromycin and sensitive to clindamycin, have the positive result of D-test(induced resistance to clindamycin)69.72% and 30.58%, separately.The total percentage of the Staphylococcus that got D-test positive occupied the part of 24.48%, meanwhile, the D-test positive bacterial strain that got resistent to erythromycin and sensitive to clindamycin occupied the part of 30.58%.Conclusion:We should pay more attention to the clindamycin drug resistance induced by erythromycin.The development of antibiotic sensitivity tests, D-test, and the detection of Staphylococcus resistance in clindamycin-induced, guide the clinical reasonable usage of macrolides antibiotics and clindamycin.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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