Title: The expression of of STAT3 activation in esophageal squmous cell carcinoma
Abstract: Objective To explore the possibility role of STAT3,phosphorylation STAT3(p-STAT3) and STAT3 mRNA expression in esophageal squmous cell carcinoma.Methods Detected the tissues in 60 cases of esophageal squmous cell carcinoma with STAT3,p-STAT3 in protein and mRNA expression levels by immunohistochemistry and in situ hybridization, then compared with 40 cases of normal esophageal mucosa.Results The STAT3 protein,p-STAT3 protein,STAT3 mRNA expression were all significantly higher in esophageal squmous cell carcinoma than those of the normal esophageal mucosa (P0.01).Along with the activation of cells the STAT3 was highly expressed.The expression of STAT3 protein and p-STAT3 protein were consistency(r =0.735,P0.05),the similar to the expression of STAT3 protein and STAT3 mRNA (r = 0.564,P0.05).Conclusion It validated that the sustainability of STAT3 activation may play a role in the pathological change of esophageal squmous cell carcinoma.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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