Title: Factors affecting postoperative prognosis of elderly patients with hepatocellular carcinoma
Abstract: Objective To determine factors affecting postoperative survival of elderly patients with hepatocellular carcinoma (HCC). Methods A retrospective analysis of consecutive 54 elderly patients undergoing hepatectomy for hepatocellular carcinoma from Jan 1995 to Dec 2002 was performed. The data were analyzed by Kaplan-Meier method and Cox regression. Results Univariate analysis and Cox regression showed Child Pugh grading, vessel invasion, satellite nodule formation, Edmondson Steiner grading, intrahepatic recurrence and distant metastasis all related to postoperative overall survival or disease-free survival of the elderly with hepatocellular carcinoma (all P0.05). Of them, Child-Pugh grading and vessel invasion were independent risk factors for overall survival (Relative risks were 3.37 and 2.73, respectively, all P0. 05), and vessel invasion independently influenced disease-free survival (Relative risk was 3.19, P0.05). Conclusions Biological behaviors of the tumor and liver function status are major factors influencing the prognosis of hepatocellular carcinoma in the elderly.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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