Title: Clinical analysis of adverse reactions of ankylosing spondylitis patients treated by different TNF-inhibitors
Abstract:Objective To study immunologic mechanisms induced by different TNF-inhibitors in ankylosing spondylitis treatment. Methods A total of 180 patients with ankylosing spondylitis received TNFα inhibitors ...Objective To study immunologic mechanisms induced by different TNF-inhibitors in ankylosing spondylitis treatment. Methods A total of 180 patients with ankylosing spondylitis received TNFα inhibitors were collected. Distribution of different TNF-inhibitors and adverse reactions of patients were observed. Results Three kinds of TNFinhibitors were used. Among the patients, 50 were treated with Infliximab; 50, with Adalimumab; and 80, with Etanercept. The adverse reaction rates were 14%, 13%, 4%, and 6% in Infliximab, Etanercept( domestic), Etanercept( imported), and Adalimumab, respectively. The humanized TNF-inhibitor was safer than the human-mouse chimeric TNFinhibitor. Conclusion The human-mouse chimeric TNF-inhibitor was more likely to induce adverse reactions, which might be related to its immunogenicity.Read More
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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