Title: The expression and significance of TRAIL recepters mRNA in hepatocellular carcinoma
Abstract: Objective To explore the mechanism and clinical significance of TRAIL-induced apoptosis in hepatocellular carcinoma (HCC) by detecting the expression of DR4,DR5,DcR1 and DcR2 mRNA,the main recepters of the TRAIL,in liver tissue of patients with HCC. Methods DR4,DR5,DcR1 and DcR2 mRNA expression and its levels were assessed in 23 cases of normal liver tissue,40 cases of para-liver cancer tissuse and 40 cases of HCC tissues with semi-quantitative reverse transcription polymerase chain reation (RT-PCR) method. Results (1) There was no different expression levels of DR4 and DR5mRNA among the normal liver tissue,para-liver cancer tissuse and HCC tissue (P 0.05);(2) The positive expression level of DcR1 and DcR2 mRNA in the normal liver tissue and para-liver cancer tissuse was significantly higher than in HCC tissue (P 0.05);(3) Statistical correlation among the expression changes of DR4 or DR5 mRNA and patient's age,size and differentiation of the tumor,plasma AFP levels and HBsAg was existed. Conclusion TRAIL receptors expression was prevalent in HCC,which was different from that in normal liver tissue;The expression of DR4 or DR5 was closely correlated with HCC pathological status.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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