Title: Variation of insulin-like growth factor II in serum and tissue of patients with cervical cancer and its clinical significance
Abstract: Objective To investigate the expression of serum and tissue insulin-like growth factor Ⅱ(IGF-Ⅱ)in patients with cervical cancer,and to evaluate its clincial significance in the ocuurence and development of cervical cancer.Methods The serum level of IGF-Ⅱwas examined by radioimmunoassay(RIA),and the expression level of IGF-Ⅱ in the tumor and normal tissue was detected with immunohistochemical technique.The relationship of tissue expression level of IGF-Ⅱ and the clinicopathological parameters was analyzed as well.Results The serum IGF-Ⅱ levels in cervical cancer group and the control group were(1.98±0.53)μg/L and(0.51±0.16)μg/L,respectively.There was significant difference between them(P0.01);the serum IGF-Ⅱ level was decreased significantly after therapy.The serum IGF-Ⅱ level in lymph node metastasis group was obviously higher than that in lymph node non-metastasis group [(2.26±0.32)μg/L vs(1.73±0.42)μg/L,P0.01].The positive expression rate of IGF-Ⅱ in cervical cancer tissues was 73.3%,significantly higher than that in normal cervical tissues(10.0%)(P0.01).The positive expression of IGF-Ⅱ was closely correlated with different clinical stage and differentiation degree of carcinoma(P0.01).The positive expression rate of IGF-Ⅱ in lymph node metastasis group was significantly higher that in lymph node non-metastasis group(χ2=8.69,P0.01).Conclusion The excessive expression of IGF-Ⅱ may be correlated with the genesis,invasion and metastasis of cervical cancer.The expression of IGF-Ⅱ may be useful marker of diagnosis and prognosis evaluation of cervical cancer.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot