Title: Evaluation for Effects of Routine Administration of Hepatitis B Vaccine and Hepatitis B Immunoglobulin on Preventing Mother-to-Infant Transmission of HBV-infected Mothers with Negative HBeAg
Abstract: Objective:To investigate the effect of hepatitis B vaccine and hepatitis B immunoglobulin (HBIG) in routine application to prevent mother-to-infant transmission of HBV-infected mothers with negative HBeAg,and to clarify whether HBIG in pregnancy women,different delivery modes,or feeding practices have an impact on perinatal HBV infection.Methods:Totally 231 HBsAg-positive with HBeAg-negative mothers and their 252 children,born January 2004 to March 2012,were followed-up.Relevant information such as administration of hepatitis B vaccine and HBIG in infants,delivery modes and feeding practices was collected.HBV serologic markers in cord blood were tested in 199 newborn infants.Results:Children′s average age was 3.3±2.3 years.Although 32 (16.08%) children showed HBsAg-positive in their cord blood,all 252 children were negative at the follow-up moment for both HBsAg and anti-HBc,and the positive rate of anti-HBs was 74.21%.The positive rate of anti-HBs in 92 children of the 87 mothers administered HBIG during pregnancy was 65.22%,while that in 150 children of the 137 women without HBIG was 73.33% (χ2=1.797,P0.05).The anti-HBs positive rate in 108 children delivered with cesarean section was similar to that in 144 other children delivered spontaneously (76.85% vs 72.22%,χ2=0.691,P0.05).The positive rate of anti-HBs in 111 children with breastfeeding,65 with artificial feeding,and 76 with mixed feeding were 68.47%,78.46%,and 78.95%,respectively (χ2=3.417,P0.05).Conclusion:With the availability of current immunoprophylaxis,infants of HBV-infected mothers with negative HBeAg are scarcely infected with HBV.Detection of HBsAg in cord blood is useless to define the perinatal infection.HBIG administration in pregnant women,cesarean section,and artificial feeding have no effect on preventing perinatal HBV infection and enhancing the anti-HBs response.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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