Title: The efficacy of mood stabilizer for prevention of switch to mania in the first episode of depression
Abstract: Objective To evaluate the efficacy of mood stabilizer for prevention of switch to mania in the first episode of depression.Methods One hundred and six inpatients diagnosed first episode of depression were randomly assigned to venlafaxine XR with Mg Valproate treatment group(combined treatment group) and venlafaxine XR treatment alone group(mono treatment group).The patients were assessed with Bech-Rafaelson Mania Scale(BRMS),Hamilton Rating Scale for Depression-17 Items(HAMD17),Montgomery-Asberg Depression Rating Scale(MADRS),Clinical Global Impression for Severity(CGI-S) and Treatment Emergent Symptom Scale(TESS) at baseline,week2,4,8,12 and 24 after treatment.Results Fifty two patients received the combined treatment while fifty four patients treated with mono treatment.At the end of 24 weeks treatment,one patient in combined group and eight patients in mono treatment group experienced manic episode,there was a significant difference between two groups.The remission rate and response rate did not reach a significant difference between two groups as 54% and 77% in the combined treatment group and 50% and 70% in the mono treatment group respectively.Some side effects such as decrease of appetite nausea,vomiting,somnolence,fatigue were more frequently seen in the combined group than in the mono treatment group.Conclusion Mood stabilizer combined antidepressant in the use of first episode depression can reduce the probability of switch to manic episode,though some adverse reactions are more frequent in the combined treatment,the tolerability is similar between combined treatment and antidepressant alone treatment.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot