Title: The study on the efficient synthesis of N-alkyl-aminoacrylate
Abstract:An efficient synthesis of β-enaminoesters has been achieved via a one-pot reaction involving ethyl acetate,ethyl formate,amine and sodium hydride.The factors included the solvent,the ratio and the bas...An efficient synthesis of β-enaminoesters has been achieved via a one-pot reaction involving ethyl acetate,ethyl formate,amine and sodium hydride.The factors included the solvent,the ratio and the base was investigated and the optional experimental conditions are as follows: toluene as the solvent,sodium hydride as a base,the ratio of n(ethyl acetate)∶n(sodium hydride)∶n(ethyl formate)∶n(dimethylamino hydrochloride) was 1.0∶1.0∶1.2∶1.2,the yield of the desired product can up to 73%.Various β-enamioesters were prepared in the middle-yields from the corresponding substituted amino acid hydrochloride salts.Interestingly,the secondary amine gave the products of E-isomers,while the primary amine gave the mixture of E and Z isomers in which the Z isomer is the major product.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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