Title: Expressions of Matrix Metalloproteinase 7 and Its Tissue Inhibitor 1 in Pancreatic Carcinoma
Abstract: Objective: Our aims were to evaluate the expressions of metalloproteinase 7 and tissue inhibitors of metalloproteinase 1 in human pancreatic tissue and pancreatic carcinoma tissue and to investigate the role of MMP 7 and TIMP 1 in the progression, transformation and invasiveness of human pancreatic carcinoma. Methods: A total of 32 cases of pancreatic carcinoma and 4 of normal pancreatic tissue, were tested for expressions of MMP 7 and TIMP 1 by using immunohistochemical methods and image analysis technique. Results: The integrated optical density averages of MMP 7 and TIMP 1 in normal human pancreatic tissue were significantly lower than those in pancreatic carcinoma tissue (P0.01). In cases with lymph node or liver metastasis, the averages were (68.57±31.65) and (52.86±33.47), which were significantly higher than (43.03±36.12) and (29.19±26.57) in those without metastasis ( P0.05). Conclusion: The increased expression of MMP 7 and TIMP 1 were related to the progression of pancreatic carcinoma and might indicate the biological aggressiveness and malignancy of pancreatic carcinoma.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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