Title: Expression and clinical significance of survivin and cyclin D1 protetin in primary hepatocellular carcinoma
Abstract: Objective:To investgate the expression and the clinical significance of Survivin and CyclinD1 with the possible mechanism in the primary hepatocellular carcinoma(HCC) .Methods:SP immunohistochemical staining was performed to detect the expression of Survivin and CyclinD1 protein in 50 HCC tissues and 20 normal liver tissues.Results:The positive rate of Survivin expression in HCC were 66.0%(33/50) ,which was significantly higher than that in normol liver tissues(negative expression) (P0.00l) ,the expression of Survivin was correlated with intrahepatic dissemination and multiple masses(P=0.019,P=0.030) ,The positive rate of CyclinD1 expression in HCC was 44.0%(22/50) ,which was significantly higher than that in normol liver tissues(negative expression) (P0.001) ,the expression of CyclinD1 was correlated with intrahepatic dissemination and tumor grade(P=0.035,P=0.036) .There was a positive correlation between Survivin expression and CyclinD1 expression(r=0.466,P0.001) .The high Survivin and CyclinDl expression was associated with the survival stage less than three years(P=0.018,P=0.013) .Conclusions:The experiment suggests that Survivin and CyclinDi may play certain roles in the oncogenesis and progression of HCC,but to diffrent extent,joint detection of the Survivin and CyclinDl gene products can supply certain evidence on prognosis of primary hepatocellular carcinoma.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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