Title: Research advances in coronary no-reflow phenomenon
Abstract: The no-reflow phenomenon is the inability to perfuse a portion of the myocardium after re-establishment of patency of a previously occluded epicardial coronaryartery.No-reflow may impede the ability of the infarct to heal and prevent delivery of pharmaceutical agents into the infarct zone and have effects in the formation of future collateral circulation.A large area of no reflow predicts worse infarct expansion and left ventricular dilation.No-reflow phenomenon is likely multifactorial,endothelial damage,platelet,fibrin and leukocyte plugging may result in it.Application of diagnostic technique such as myocardial contrast echocardiography and Doppler wire improved detection rate of no-reflow phenomenon.Pharmacological interventions such as platelet glycoprotein Ⅱb/Ⅲa receptor antagonism,hypothermia,ischemic conditioning and distal protector can reduce no-reflow.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot