Title: Effect of dexmedetomidine hydrochloride on perioperative stress response to the patients with spinal fracture surgery
Abstract: Objective To observe the effect of dexmedetomidine using for general anesthesia maintain on perioperative stress response to the patients with spinal fracture surgery.Methods Sixty patients with elective surgery of spinal fracture were randomly divided into the test group(n=30) and the conventional treatment group(n=30).Immediately after induction of anesthesia,test group received 1 μg·kg-1 dose of dexmedetomidine by i.v.,then was pumped continuously by 0.5-0.7 μg·kg-1·h-1 to maintain.In conventional group,propofol was pumped by 4-6 mg·kg-1·h-1 as a control.Mean arterial pressure(MAP),heart rate(HR) before 10 min of induction(T0),immediately after tracheal intubation(T1),60 min after the beginning of surgery(T2),surgery end(T3),after extubation(T4) were monitored.Blood samples of 3 ml were extracted from fore arm for detecting blood glucose and serum cortisol levels at T0、T2 and T3.An additional dose of fentanyl,awakening time,and extubation cough reaction ratings were all recorded.Results In test group,MAP at T1、T4 were higher than at T0(P0.05),and lower than those in conventional group(P0.05).HR at T1,T4 were higher than T0 in both groups(P0.05),and from T2 to T4 in test group were lower than those in conventional group.Blood glucose and serum cortisol levels showed no differences at each time point in test group1(P0.05),blood glucose levels at T2,T3 and cortisol levels at T3 were higher than at T0 in conventional group(P0.05).Blood glucose at T3 in test group were lower than in conventional group(P0.05).Awakening time was shorter and extubation cough reaction ratings were lower in test group than those in conventional group(P0.01).Conclusion Dexmedetomidine used in general anesthesia as a substitute to propofol for the paients with spinal fracture surgery can inhibit to a certain extent the increasing of the blood glucose and serum cortisol,shorten the postoperative awakening time,decrease the extubation cough reaction ratings,keep the hemodynamic stability and then reduce the perioperative stress response.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot