Title: A Clinicopathologic Study of Primary Epithelioid Sarcoma of Skina
Abstract: Objective To explore the pathoclinical characteristics immunophonetype and its biological behaviour of primary epithelial sarcoma.Methods Two cases of primary epithelial sarcoma of skin were studied by using microscope observation and immunohistochemistry and analyse their characterstics of clinic、cytological smear and pathohistology.Results The group of tumors were all located in skin.Microscopically,tumor showed an invasive growth and nodulous arrangement and was made up of two kinds of cells,relativepart of cells were characterized by multangular or oval and round cell with richful eosinophilic cytoplasm,other cells were fatty and spindle just like fibroblast.The tumor nodule's central zone that was always degenerative and necrosive that surrounded by the two kinds cells.Immunohistochemically,tumor cells showedintense positive staining for EMA、Cytokeratin and Vimentin,only showed weak positive staining for S-100、CD_ 34,while also showed dubious positive karyon staining for CD_ 20 and CD_3,other results of immnuohistochemistry were all negative.Conclusion The tumor is quite difficult to diagnose only by microscope for its infrequency and various morphological features.No diagnostic particularity only bycelluar smear.Only based on histopathological characteristics with the results of immunohistochemistry,a definite pathological diagnosis of the tumor can be got.Its prognosis is very poor and a patient needs to have a marginal or even a radical resection.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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