Title: Absorption kinetics of ribavirin in rats in situ
Abstract: Objective To determine the absorption characters of ribavirin from various intestinal segments. Methods The absorption kinetics was investigated using the in situ perfusion method in rats.The concentration change of ribavirin in intestinal liquid of rats was measured by HPLC.Results Ribavirin has the better absorption in the upper parts of the small intestines.The absorption rate constants were (0.097 00),(0.015 00),(0.001 10),(0.000 05 h~(-1)) respectively at duodenum,jejunum,ileum and colon.Conclusions The absorption of ribavirin complies with the passive transport mechanism and first order kinetics.The main intestinal segments of the drug absorption is duodenum and jejunum,in colon the drug absorption amount is little.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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