Title: Cerebrospinal fluid interferon-gamma in the diagnosis of tuberculous meningitis
Abstract: Objective To evaluate the clinical utility of interferon-gamma(IFN-γ)in serum and cerebrospinal fluid in the diagnosis of tuberculous meningitis.Methods IFN-γlevels in serum and cerebrospinal fluid were analyzed by ELISA method in25 patients with tuberculous meningitis,31 patients with viral meningitis and 12 patients with suppurative meningitis.Results The IFN-γlevels in cerebrospinal fluid were significantly higher in the patients with tuberculous meningitis(386.3 ± 83.5)ng/L than in the patients with viral meningitis(63.4 ± 16.2)ng/L or the patients with suppurative meningitis(116.8 ±22.6)ng/L(P0.01).The overlap was very small.In contrast,the serum IFN-γlevels were very similar among the three groups(P0.05).The sensitivity,specificity and accuracy of IFN-γlevel in cerebrospinal fluid for diagnosis of tuberculous meningitis were 92.0%,95.3%and 94.1%,respectively.Conclusions Measurement of IFN-γlevel in cerebrospinal fluid may be helpful for the diagnosis of tuberculous meningitis.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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