Title: Evaluation of left ventricular structure and function types in rat heart myocardial infarction model using wideband high frequency echocardiography
Abstract:Objective To study the method using wideband and high frequency ultrasound determining the degree and type of rat heart myocardial infarction (MI). Methods Chest open surgery was performed in 48 cases...Objective To study the method using wideband and high frequency ultrasound determining the degree and type of rat heart myocardial infarction (MI). Methods Chest open surgery was performed in 48 cases of SD rats, of these, the left anterior descending (LAD) coronary artery of 41 rats were ligated as study group; and the remaining 7 rats were kept as a sham group without ligation of LAD while open chest. Four weeks after the surgery, the rats were checked on echocardiography with a 10-22 MHz frequency transducer to measure the myocardial infarction (MI) size of the left ventricle (LV). The rats were then sacrificed and the hearts were sliced and stained with Masson Trichrome method to compare the changes of echo images with pathology. Results There were different changes in the B-mode images and M-mode images according to the type of MI. The anterior wall of LV was thinner in small, moderate and large size MI; the anterior and lateral wall were thinner in moderate and large size MI respectively; in large size MI, the posterior wall, anterior and lateral wall were all thinner. The infarcted region was echogenic and heterogeneous in texture, and the endocardial shape was deformed with the degree of MI both in short axis and long axis section of the LV. The position and size of infarction was coincident with pathological changes. The fraction shortening (FS) value from M-mode was gradually reduced from small size to large size of MI. Conclusions Transthoracic wideband, high frequency ultrasound may detect the LV structure, texture and heart functions of rat MI model in short axis and long axis clearly and it can evaluate the MI position, size and degree accurately.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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