Publication Information

{'id': 'https://openalex.org/W2388501386', 'doi': None, 'title': 'p-Methoxycinnamaldehyde levofloxacin-3-ylhydrazone induces apoptosis of human hepatocarcinoma SMMC-7721 cells', 'display_name': 'p-Methoxycinnamaldehyde levofloxacin-3-ylhydrazone induces apoptosis of human hepatocarcinoma SMMC-7721 cells', 'publication_year': 2011, 'publication_date': '2011-01-01', 'ids': {'openalex': 'https://openalex.org/W2388501386', 'mag': '2388501386'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTotal-YAOL201106014.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764632464', 'display_name': 'Zhongguo yaolixue tongbao', 'issn_l': '1001-1978', 'issn': ['1001-1978'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4361727491', 'host_organization_name': 'Chinese Pharmacological Society', 'host_organization_lineage': ['https://openalex.org/P4361727491'], 'host_organization_lineage_names': ['Chinese Pharmacological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035199180', 'display_name': 'Jianmin Fu', 'orcid': 'https://orcid.org/0000-0002-7368-0751'}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'FU Jian-min', 'raw_affiliation_strings': ['WANG de-hui1,SUN Jin-ping1,KANG Yu-hua1, HUANG-FU Chao-shen2,HU Guo-qiang3,LIU Bin1'], 'affiliations': [{'raw_affiliation_string': 'WANG de-hui1,SUN Jin-ping1,KANG Yu-hua1, HUANG-FU Chao-shen2,HU Guo-qiang3,LIU Bin1', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5035199180'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10274', 'display_name': 'Synthesis and biological activity', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10274', 'display_name': 'Synthesis and biological activity', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/agarose-gel-electrophoresis', 'display_name': 'Agarose gel electrophoresis', 'score': 0.62310636}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.5027983}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.81751597}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.7304897}, {'id': 'https://openalex.org/C2778271344', 'wikidata': 'https://www.wikidata.org/wiki/Q903395', 'display_name': 'Agarose gel electrophoresis', 'level': 3, 'score': 0.62310636}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.53055245}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.5027983}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4737214}, {'id': 'https://openalex.org/C196795494', 'wikidata': 'https://www.wikidata.org/wiki/Q1624817', 'display_name': 'TUNEL assay', 'level': 3, 'score': 0.46462828}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.4396428}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.43828058}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.43652633}, {'id': 'https://openalex.org/C74864618', 'wikidata': 'https://www.wikidata.org/wiki/Q2332446', 'display_name': 'Staining', 'level': 2, 'score': 0.42020944}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38678247}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24915972}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.09453955}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTotal-YAOL201106014.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764632464', 'display_name': 'Zhongguo yaolixue tongbao', 'issn_l': '1001-1978', 'issn': ['1001-1978'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4361727491', 'host_organization_name': 'Chinese Pharmacological Society', 'host_organization_lineage': ['https://openalex.org/P4361727491'], 'host_organization_lineage_names': ['Chinese Pharmacological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.47, 'id': 'https://metadata.un.org/sdg/2', 'display_name': 'Zero hunger'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032666680', 'https://openalex.org/W2474253747', 'https://openalex.org/W2413902205', 'https://openalex.org/W2411193031', 'https://openalex.org/W2393788118', 'https://openalex.org/W2385739811', 'https://openalex.org/W2382423778', 'https://openalex.org/W2380827943', 'https://openalex.org/W2379597309', 'https://openalex.org/W2375903679', 'https://openalex.org/W2373490020', 'https://openalex.org/W2373118421', 'https://openalex.org/W2371139612', 'https://openalex.org/W2368523882', 'https://openalex.org/W2355974412', 'https://openalex.org/W2355707334', 'https://openalex.org/W2352252927', 'https://openalex.org/W2061084931', 'https://openalex.org/W2007591319', 'https://openalex.org/W1930282135'], 'abstract_inverted_index': {'Aim': [0], 'To': [1], 'study': [2], 'the': [3, 33, 36, 42, 112, 115, 129], 'effect': [4, 38], 'of(S)': [5], 'N-(3-p-methoxylphenyl)-6-fluoro-7-(4-methylpiperazin-1-yl)-1,8-(3,1-propoxy)-quinolin-4(1H)-one-3-carbonyl': [6], 'hydrazine(FQ-10)': [7], 'on': [8, 41], 'apoptosis': [9, 50, 116, 190], 'of': [10, 19, 32, 39, 99, 105, 114, 128, 161, 166, 173, 179, 189, 191], 'hepatocarcinoma': [11], 'SMMC-7721': [12, 27, 100, 192], 'cells': [13, 28, 34, 101, 123], 'in': [14, 29, 94, 121, 152, 186], 'vitro.Methods': [15], 'With': [16], 'different': [17, 22, 103], 'concentrations': [18, 104], 'FQ-10': [20, 40, 90, 187], 'at': [21, 91], 'times': [23], 'used': [24], 'to': [25], 'treat': [26], 'vitro,the': [30], 'proliferation': [31, 44, 86], 'and': [35, 58, 74, 124, 146, 169], 'inhibition': [37], 'cell': [43, 85, 140], 'were': [45, 78, 184], 'examined': [46], 'by': [47, 53, 67, 80, 89, 136], 'MTT': [48], 'assay.Cell': [49], 'was': [51, 65, 87, 150], 'determined': [52], 'Hoechst': [54], '33258/PI': [55], 'fluorescence': [56], 'staining,TUNEL': [57], 'agarose': [59, 137], 'gel': [60, 138], 'electrophoresis': [61], 'method.Mitochondrial': [62], 'membrane': [63, 131], 'potential(MMP,△ψm)': [64], 'measured': [66], 'high': [68], 'content': [69], 'screening': [70], 'image': [71], 'system.The': [72], 'caspase-9,caspase-8,caspase-3,p53,Bcl-2': [73], 'Bax': [75], 'protein': [76, 159, 171], 'expressions': [77], 'detected': [79], 'Western': [81], 'blot': [82], 'analysis.Results': [83], 'The': [84, 181], 'inhibited': [88], '0.625~10.00': [92], 'μmol·L-1': [93], 'a': [95, 125], 'time-and-dose': [96], 'dependent': [97], 'manner.Treatment': [98], 'with': [102, 176], 'FQ-Henan': [106], '10': [107], 'for': [108], '24': [109], 'h': [110], 'increased': [111, 158], 'percentage': [113], 'cells(P0.05).The': [117], 'typical': [118], 'ladder': [119], 'DNA': [120], 'apoptotic': [122, 141, 154], 'concomitant': [126], 'dissipation': [127], 'mitochondrial': [130], 'potential': [132], 'could': [133, 143], 'be': [134, 144], 'observed': [135, 151], 'electrophoresis.Typical': [139], 'features': [142], 'seen': [145], 'specific': [147], 'PI': [148], 'staining': [149], 'late': [153], 'cells.In': [155], 'addition,FQ-10(3.0~7.39': [156], 'μmol·L-1)': [157], 'expression': [160, 172], 'p53,Bax,caspase-9,caspase-3,separately,and': [162], 'induced': [163], 'cytosolic': [164], 'accumulation': [165], 'activities': [167], 'caspase-9': [168], 'caspase-3,whereas': [170], 'Bcl-2': [174], 'decreased': [175], 'no': [177], 'change': [178], 'caspase-8.Conclusion': [180], 'mitochondrial-dependent': [182], 'pathways': [183], 'involved': [185], 'induction': [188], 'cells.': [193]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2388501386', 'counts_by_year': [], 'updated_date': '2024-12-07T01:29:38.928318', 'created_date': '2016-06-24'}