Title: Serum Interleukin-1β and HP Infection in Atrophic Gastritis
Abstract:Objective To observe the effect of interleukin-1β(IL-1β) in atrophic gastritis and to identify the relationship between IL-1β level and helicobacter pylori(HP) infection.Methods 52 cases of superficia...Objective To observe the effect of interleukin-1β(IL-1β) in atrophic gastritis and to identify the relationship between IL-1β level and helicobacter pylori(HP) infection.Methods 52 cases of superficial gastritis and 50 cases of atrophic gastritis were investigated.The trail has four groups: group A: superficial gastritis with HP negative subjects;group B: superficial gastritis with HP positive subjects;group C: atrophic gastritis with HP negative subjects;groups D: atrophic gastritis with HP positive subjects.Serum IL-1β level was examined by enzyme-linked immunosorbent assay.HP infection was determined by 14C-urea breath test(14C-uBT).Results Serum IL-1β levels in atrophic gastritis were higher than those in superficial gastritis.Especially serum IL-1β in atrophic gastritis with HP positive subjects(P0.01)and atrophic gastritis with HP negative subjects(P0.05).In superficial gastritis with HP infection serum IL-1β were higher than HP negative subjects,but there was no significance(P0.05).Conclusion IL-1β may contribute to the pathogenesis of atrophic gastritis.Inducible generation of IL-1β may one of the mechanisms to explain the link between HP infection and atrophic gastritis.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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