Publication Information

{'id': 'https://openalex.org/W2388222041', 'doi': None, 'title': 'Research progress of Hedgehog signaling pathway and its inhibitors in cancers', 'display_name': 'Research progress of Hedgehog signaling pathway and its inhibitors in cancers', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W2388222041', 'mag': '2388222041'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-SMHX201401019.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306505991', 'display_name': 'Chemistry of Life', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101772601', 'display_name': 'Da Wang', 'orcid': 'https://orcid.org/0000-0003-1189-4663'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wang Da', 'raw_affiliation_strings': ['Alan K'], 'affiliations': [{'raw_affiliation_string': 'Alan K', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046362581', 'display_name': 'WU Huijia', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27357992', 'display_name': 'Dalian University of Technology', 'ror': 'https://ror.org/023hj5876', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27357992']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'WU Huijia', 'raw_affiliation_strings': ['School of Life Science and Technology,Dalian University of Technology'], 'affiliations': [{'raw_affiliation_string': 'School of Life Science and Technology,Dalian University of Technology', 'institution_ids': ['https://openalex.org/I27357992']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9811, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12820', 'display_name': 'Chromatin Remodeling and Cancer', 'score': 0.938, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/smoothened', 'display_name': 'Smoothened', 'score': 0.97563434}, {'id': 'https://openalex.org/keywords/gli1', 'display_name': 'GLI1', 'score': 0.8820106}, {'id': 'https://openalex.org/keywords/patched', 'display_name': 'Patched', 'score': 0.8121444}, {'id': 'https://openalex.org/keywords/ptch1', 'display_name': 'PTCH1', 'score': 0.54974025}, {'id': 'https://openalex.org/keywords/vismodegib', 'display_name': 'Vismodegib', 'score': 0.52277225}], 'concepts': [{'id': 'https://openalex.org/C145837895', 'wikidata': 'https://www.wikidata.org/wiki/Q18031607', 'display_name': 'Smoothened', 'level': 4, 'score': 0.97563434}, {'id': 'https://openalex.org/C2779933373', 'wikidata': 'https://www.wikidata.org/wiki/Q14886430', 'display_name': 'GLI1', 'level': 4, 'score': 0.8820106}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.8287698}, {'id': 'https://openalex.org/C2777994357', 'wikidata': 'https://www.wikidata.org/wiki/Q24781250', 'display_name': 'Patched', 'level': 4, 'score': 0.8121444}, {'id': 'https://openalex.org/C2778539099', 'wikidata': 'https://www.wikidata.org/wiki/Q6120', 'display_name': 'Hedgehog', 'level': 3, 'score': 0.7563678}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5900774}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5585953}, {'id': 'https://openalex.org/C2779477247', 'wikidata': 'https://www.wikidata.org/wiki/Q18030895', 'display_name': 'PTCH1', 'level': 4, 'score': 0.54974025}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.5253424}, {'id': 'https://openalex.org/C2779545874', 'wikidata': 'https://www.wikidata.org/wiki/Q2070286', 'display_name': 'Vismodegib', 'level': 4, 'score': 0.52277225}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3995993}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTOTAL-SMHX201401019.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306505991', 'display_name': 'Chemistry of Life', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.75, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3145072879', 'https://openalex.org/W3084734383', 'https://openalex.org/W3030289297', 'https://openalex.org/W2953533523', 'https://openalex.org/W2953212549', 'https://openalex.org/W2930930236', 'https://openalex.org/W2587792028', 'https://openalex.org/W2416916914', 'https://openalex.org/W2403638555', 'https://openalex.org/W2378487773', 'https://openalex.org/W2162564067', 'https://openalex.org/W2153260902', 'https://openalex.org/W2150953401', 'https://openalex.org/W2121718175', 'https://openalex.org/W2066122732', 'https://openalex.org/W2059902429', 'https://openalex.org/W1999379933', 'https://openalex.org/W1980888416', 'https://openalex.org/W1584555042', 'https://openalex.org/W151808565'], 'abstract_inverted_index': {'The': [0, 100], 'Hedgehog(HH)': [1], 'pathway': [2, 7, 59, 82, 113], 'is': [3], 'a': [4, 125], 'conserved': [5], 'signaling': [6], 'essential': [8], 'for': [9, 102], 'embryonic': [10], 'development': [11, 116], 'and': [12, 35, 51, 87, 114, 119], 'organ': [13], 'formation.': [14], 'It': [15], 'can': [16], 'be': [17], 'abnormally': [18], 'activated': [19], 'by': [20], 'the': [21, 42, 57, 67, 80, 97, 111], 'loss': [22], 'or': [23, 30], 'mutation': [24, 27], 'of': [25, 28, 33, 44, 56, 79, 89, 96, 110, 128], 'Patched(PTCH),': [26], 'Smoothened(SMO),': [29], 'abnormal': [31], 'amplification': [32], 'Gli1': [34, 37], 'increased': [36], 'protein': [38], 'stability,': [39], 'resulting': [40], 'in': [41, 66], 'occurrence': [43], 'cancers,': [45], 'such': [46], 'as': [47], 'basal': [48], 'cell': [49], 'carcinoma': [50], 'medulloblastoma.': [52], 'Thus': [53], 'targeting': [54], 'elements': [55, 94, 108], 'HH': [58, 81, 98, 112, 132], 'may': [60, 106, 123], 'offer': [61], 'an': [62], 'effective': [63, 120], 'therapeutic': [64], 'strategy': [65], 'fight': [68], 'against': [69], 'certain': [70], 'cancers.': [71], 'Many': [72], 'small-molecule': [73], 'inhibitors': [74], 'that': [75, 105], 'target': [76, 93, 107], 'different': [77], 'components': [78], 'have': [83], 'already': [84], 'been': [85], 'discovered,': [86], 'most': [88], 'these': [90], 'seem': [91], 'to': [92], 'upstream': [95], 'pathway.': [99], 'search': [101], 'small': [103], 'molecules': [104], 'downstream': [109], 'their': [115], 'into': [117, 131], 'potential': [118], 'anti-cancer': [121], 'drugs': [122], 'constitute': [124], 'major': [126], 'part': [127], 'future': [129], 'research': [130], 'signaling.': [133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2388222041', 'counts_by_year': [], 'updated_date': '2024-12-15T03:20:33.957193', 'created_date': '2016-06-24'}