Title: The impact of dexmedetomidine on heart rate variability during anesthesia emergence in elderly patients after total intravenous anesthesia
Abstract: Objective To evaluate the impact of dexmedetomidine on heart rate variability during anesthesia emergence in elderly patients after total intravenous anesthesia.Methods Eighty six elderly patients(age≥65 years) scheduled for abdomen surgery in total intravenous were randomly divided into receive either dexmedetomidine(group D) or saline placebo(group C) intravenously.Group D received 10 ml infusion that contained 0.5 μg/kg Dex with constant speed and group C received infusion of normal saline(NS) within ten minutes before the end of surgery.The MAP,HR,total power(TP),relative low frequency(LF),relative high frequency(HF),and the ratio of low frequency to high frequency power ratio(LF/HF) were recorded before(T_0) and 5 min(T_1) and 10 min(T_2) after drug administration,during extubation(T_3),and at 5 min(T_4) and 30min(T_5) after extubation.Meanwhile,the blood were taken for analysis of plasma epinephrine(E),norepinephrine(NE) and cortisol(Cor).Results MAP,HR,and the concentration of E,NE was significantly increased in group C after drug administration.These values in group C were higher compared with group D.The concentration of Cor in group D was significantly increased at T_3,T_4,similarly,it was higher in group C at T_2-T_4 when compared to T_0.The LF/HF was higher in group C than that of T_0 and in group D.Conclusion A single-dose bolus injection of Dex before tracheal extubation attenuates airway-circulatory reflexes and promote HRV recovery by improving the autonomic nervous balance during extubation.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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